IGHA1 and urogenital neoplasm: It is known that four-hit hypothesis in IgAN postulates a pathogenesis of this disease: increased production of galactose-deficient IgA (Gd-IgA1) cause the formation of immune complexes with anti-gd-IgA1 IgG or IgA1 antibodies, then deposit in the glomerular mesangium and subsequently result in kidney inflammation and injury [5, 6].