CD8A and metastasis: In line with the above observations, the combined SB525334 with KN046 therapy significantly increased intratumoral CD8+, IFN-γ+CD8+, and GZMB+CD8+ T cells and CD4+ and IFN-γ+CD4+ T cells in colorectal liver metastasis (Figure 6, E–G, and Supplemental Figure 3, C–F).