CD4 and lymphoma: Finally, the near universal indolence of acral CD8(+) lymphoma has led to consideration to “downgrade” the name of the entity to “lymphoproliferative disease” as now used in CD4(+) pleomorphic lymphoproliferative disorder (CSMPTCL).32 However, unlike CSMPTCL, acral CD8(+) lymphoma is clearly a monotonous, clonal, cytologically malignant, neoplastic population and often occurs with T-cell antigen loss, which are collective cardinal features of lymphoma.