FAM222A and Alzheimer disease: One RECE (chr12: 110190581 to 110190690) overlapped with an oligodendrocyte H3K27ac peak interacting with the FAM222A promoter, indicating that this RECE may control the expression of FAM222A a well-known AD risk gene (Satoh et al. 2020; Yan et al. 2020) (Fig. 5d), which was upregulated in the AD patients compared to controls (Fig. 5e).