As such, both STMN2 and UNC13A are important components of neuronal function, and given the lack of cognitive resilience and increased brain atrophies associated with TDP-43 pathology in Alzheimer’s disease [17, 18, 32, 34, 36, 37, 99], future studies should focus on exploring how these targets may contribute to neurodegeneration in Alzheimer’s disease. The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.