Notably, this relative resistance of UNC13A to TDP-43 loss occurs in SH-SY5Y cells while sequencing of this line revealed homozygosity for the ALS-associated risk allele (G) at the SNP rs12973192 that leads to an increased likelihood of UNC13A cryptic exon incorporation [16, 57]. Here, TARDBP is linked to amyotrophic lateral sclerosis.