However, we observed a significant increase of truncated STMN2 in the inferior frontal gyrus (Fig. 4a) of Alzheimer’s disease patients; whereas, full-length STMN2 RNA levels were significantly decreased in Alzheimer’s disease patients compared to controls, in all the regions tested (Fig. 4b and Sup. This evidence concerns the gene STMN2 and early-onset autosomal dominant Alzheimer disease.