In addition, germline deletion of Stmn2 in mice [26, 45, 50] or chronic reduction of Stmn2 in the nervous system of otherwise normal adult mice [56] leads to motor deficits with denervation of the neuromuscular junctions that recapitulate clinical manifestations observed in patients with ALS. Here, STMN2 is linked to amyotrophic lateral sclerosis.