We also tested misprocessing of UNC13A RNA in these areas and detected UNC13A cryptic exon in 19/38 amygdala samples and 13/27 entorhinal cortex samples from Alzheimer’s disease patients and at very low levels (qRT-PCR cycle thresholds Cts above 35 cycles) in the amygdala of 3 control individuals (Sup. This evidence concerns the gene UNC13A and early-onset autosomal dominant Alzheimer disease.