STMN2 and early-onset autosomal dominant Alzheimer disease: Inversely, STMN2 cryptic exon was detected in 2 out of 17 brains without apparent phosphorylated TDP-43 aggregates which is consistent with reports of TDP-43 nuclear loss without cytoplasmic aggregates in a subset of patients with FTD or Alzheimer’s disease [64, 87].