Notably, TDP-43 proteinopathy has also been reported in approximately one-third of Alzheimer’s disease cases, with estimates varying from 19 to 57% [5, 7, 13, 21, 29, 34, 35, 38, 54, 85, 92, 100], also referred to as Alzheimer’s disease with LATE neuropathologic changes (LATE-NC) [65–67]. This evidence concerns the gene TARDBP and proteostasis deficiencies.