Notably, previous studies observed a non-significant tendency for decreased levels of full-length STMN2 RNA in the temporal cortex and hippocampus of a subset of patients with Alzheimer’s disease [73], as well as a decrease in STMN2 RNA in inhibitory neurons and oligodendrocytes of Alzheimer’s disease patients [60]. Here, STMN2 is linked to early-onset autosomal dominant Alzheimer disease.