TARDBP and early-onset autosomal dominant Alzheimer disease: Identification of STMN2 and UNC13A disruption in Alzheimer’s disease has major implications: (1) they are both enriched in the brain, (2) they have crucial roles in maintaining neuronal function [8, 26, 42, 45, 56, 62, 63, 80, 84, 95] and (3) they are two prominent targets of TDP-43 for which therapeutic approaches are in development [10, 16, 42, 57, 62].