Notably, we observed a correlation between the levels of STMN2 and UNC13A cryptic exons detected in the amygdala of Alzheimer’s disease patients (Fig. 2f, Spearman r = 0.78, p < 0.0001), strengthening the link between detection of cryptic exons and loss of TDP-43 function. Here, TARDBP is linked to early-onset autosomal dominant Alzheimer disease.