TARDBP and neurodegenerative disease: Importantly, strategies to either target TDP-43 cellular mislocalization [1, 4, 11, 23, 47, 58, 70, 75, 88, 89] or to prevent cryptic splicing of specific TDP-43 targets [10] are emerging for clinical development in neurodegenerative diseases with TDP-43 proteinopathy.