To test whether TDP-43 pathology in Alzheimer’s disease patients leads to RNA mis-processing of STMN2 and UNC13A, we performed qRT-PCR using RNA from the amygdala and entorhinal cortex of 38 Alzheimer’s disease patients and 14 age-matched control individuals without significant confounding neuropathology (Sup. Here, UNC13A is linked to early-onset autosomal dominant Alzheimer disease.