Here, TDP-43 pathology was assayed in 38 of the Alzheimer’s disease patients with 18 showing accumulation of phosphorylated TDP-43, consistent with previous reports of approximately 50% of Alzheimer’s disease patients having TDP-43 pathology [5, 7, 13, 21, 29, 34, 35, 54, 92]. This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.