Interestingly, whilst p-tau Ser356 and AT8 were found to co-localise with a similar percentage of pre-synaptic terminals (median of 1.38% (Fig. 3c) and 1.60% (Fig. 3d), respectively), the percentage of synaptophysin puncta that co-localised with both tau epitopes, (whilst still significantly higher in AD than controls (*F(1,7.08) = 10.5, p = 0.014)), was considerably smaller (median of 0.36% (Fig. 3e)). Here, SYP is linked to Alzheimer disease.