MAPT and Alzheimer disease: There was a significant increase in p-tau Ser356 in Braak VI AD brains compared to Braak 0–I control brains (Fig. 1c, multiple comparisons test: ***p = 0.0009), and a strong trend for increase between Braak III–IV and Braak VI (Fig. 1c, multiple comparisons test: p = 0.053).