These include both primary tauopathies, such as progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and frontotemporal dementias (FTD) with tau pathology, and secondary tauopathies, such as Alzheimer’s disease (AD), where accumulation of amyloid-beta (Aβ) is thought to initiate the disease cascade [30, 63]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.