SYP and Alzheimer disease: Whilst largely undetectable in control cases (Fig. 3a), both p-tau Ser356 (Fig. 3c) and AT8 (Fig. 3d) were found to co-localise with synaptophysin in AD cases (**F(1,7.14) = 18.7, p = 0.0033 and **F(1,7.13) = 14.6, p = 0.0063, respectively).