Of note, Rai (also known as ShcC, Shc3) is overexpressed in tumor mass compared with normal tissue in CRC patients (TCGA CRC dataset COAD accessed via the UCSC Xena platform (http://xena.ucsc.edu/) and GENT2 database: http://gent2.appex.kr). The gene discussed is SHC3; the disease is neoplasm.