Moreover, while our data show a significant upregulation of Rai expression in TILs compared to PBLs or surrounding healthy tissue of the same patient, we documented a variability in Rai expression in TILs among CRC patients, suggesting that Rai expression levels in TILs of CRC patients might be explored as a potential new biomarker of T cell exhaustion and a predictive biomarker for anti-PD-1 response. The gene discussed is SHC3; the disease is colorectal carcinoma.