However, one significant limitation is that our transcriptome sequencing only revealed one involved pathway, the EGF/PI3K/AKT pathway, based on the most highly‐expressed miRNAs; other possible genes and pathways involved have not been fully investigated, which will be the subject of future studies, in order to fully optimize the hydrogels to aid in MI treatment. Here, EGF is linked to myocardial infarction.