INS and obesity due to melanocortin 4 receptor deficiency: However, in individuals with obesity where the insulin/phosphatidylinositol 3‐kinase (PI3K)‐protein kinase B (AKT) signaling is impaired, adipose tissue fails to respond effectively to insulin, resulting in elevated levels of circulating non‐esterified fatty acids (NEFAs) and subsequent metabolic diseases associated with obesity.1, 2, 3