To examine the regulatory effects of TGF‐β inhibition on the lipid and glucose metabolic functions of atrophied adipose tissue, we utilized a lipodystrophy animal model, ap2‐SREBP‐1c mice,28 and administered in vivo injections of the small molecule compound SB431542 to inhibit TGF‐β. Here, SREBF1 is linked to lipodystrophy.