However, in individuals with obesity where the insulin/phosphatidylinositol 3‐kinase (PI3K)‐protein kinase B (AKT) signaling is impaired, adipose tissue fails to respond effectively to insulin, resulting in elevated levels of circulating non‐esterified fatty acids (NEFAs) and subsequent metabolic diseases associated with obesity.1, 2, 3. Here, INS is linked to metabolic disease.