The main research hotspots in the pathogenesis of psoriasis are as follows: (1) The interaction between innate and adaptive immunity and the related inflammatory loop dominated by Th17 cells and IL‐23/IL‐17 axis are still the key mechanisms of psoriasis; (2) molecular genetic studies represented by Long Non‐Coding RNA (LncRNA); (3) integrated research of multi‐omics techniques represented by gut microbiota; and (4) Exploring the comorbidity mechanism of psoriasis represented by Metabolic Syndrome (MetS). The gene discussed is IL17A; the disease is psoriasis.