GDF15 and atherosclerosis: Hypertriglyceridemiais an important risk factor for atherosclerosis,60,61 and this may relate to inflammation, which is also supported bythe aggregation of triglyceride features, the LDL-receptor, GDF-15,FGF-21, tPA, and uPAR in one omics subpattern that also correlatedwith chronic inflammatory factors like age and BMI.62 However, mechanistic interpretations are made difficultdue to the complex relationship of OC concentrations in tissues withBMI and blood lipids: OCs are lipid-soluble and may be sequesteredin adipocytes and transported to LDL particles.