Notably, interaction between NUP98 fusion protein, the non-specific lethal (NSL) histone-modifying complex and KMT2A-menin is deemed essential for induction of leukemia and aberrant HOXA, HOXB and MEIS1 transcription (Rio-Machin et al., 2017; Shima et al., 2017; Xu et al., 2016a, b) (Fig. 1C). Here, KMT2A is linked to leukemia.