KMT2A (also known as MLL) is also recurrently rearranged in acute lymphoblastic leukemia (ALL) and mixed phenotype acute leukemia (MPAL) and especially infant ALL is characterized by a high incidence of KMT2A translocations in up to 75% of patients (Pieters et al., 2019). This evidence concerns the gene KMT2A and acute leukemia.