For instance, rare pediatric AML cases with PICALM::MLLT10 or DEK::NUP214 fusions have very poor outcomes and are characterized by increased expression of HOXA and MEIS1 (Novak et al., 2012; Ries et al., 2019; Sandahl et al., 2014). The gene discussed is MEIS1; the disease is acute myeloid leukemia.