A stem-cell-like expression of HOXA/MEIS1 is a hallmark of several genetic subtypes, that are prevalent in pediatric AML patients and include aberrations such as rearrangements in Histone-lysine N-methyltransferase 2A (KMT2A-r) (Armstrong et al., 2002; Ferrando et al., 2003; Kawagoe et al., 1999), mutated nucleophosmin (NPM1) and rearrangements in nucleoporin 98 (NUP98-r) (Alcalay et al., 2005; Bisio et al., 2017; Hollink et al., 2011; Mullighan et al., 2007). The gene discussed is NPM1; the disease is acute myeloid leukemia.