IMiD-mediated degradation of IKAROS sensitized leukemia cells to treatment with both menin and DOT1L inhibitors, and combination of IMiDs and menin inhibition induced apoptosis in KMT2A-r and NPM1c cell lines, intensified the transcriptional changes and prolonged survival in xenograft mice with human KMT2A-r leukemia compared to monotherapy (Aubrey et al., 2022). The gene discussed is IKZF1; the disease is leukemia.