Even though NUP98::KDM5A fusions do not seem to further deteriorate the poor prognosis of FAB M7 AML (Rooij et al., 2013), unselected childhood AML patients with these fusions show inferior and superimposable EFS and OS indicating only minimal chance of salvage after relapse (Noort et al., 2020) (Table 1). The gene discussed is NUP98; the disease is acute myeloid leukemia.