Free text terms: chronic kidney disease, CKD, chronic kidney disease, “chronic impaired kidney function”, “chronic renal dysfunction”, chronic renal impairment, chronic renal disease, chronic renal failure, chronic renal insufficiency, sodium glucose transporter 2 inhibitor, SGLT2i, mechanism, physiology, hemodynamic, metabolic, molecular.Keywords: chronic kidney failure, sodium glucose cotransporter 2 inhibitor, drug mechanism, physiology. This evidence concerns the gene SLC5A2 and chronic kidney disease.