LVH was induced by TAC in mice with global genetic ablation of FGF23 (36) and neutralization of FGF23 by treatment with FGF23-Ab did not improve LVH in CKD rats fed a high-phosphate diet and resulted in increased serum phosphate levels and aortic calcification associated with an increased risk of mortality (14). This evidence concerns the gene FGF23 and chronic kidney disease.