SCN8A and Lennox-Gastaut syndrome: Since it was identified as an epilepsy-related gene in 2012, investigators have ascertained that SCN8A mutation-related epileptic seizures are diverse, as they can be manifested as systemic tonic-clonic seizures, spasms, absence, and focal seizures, and can also be present as epileptic syndromes that include BFIE or epileptic encephalopathies, such as Lennox-Gastaut syndrome and West syndrome.