Nav channel mutations are related to epilepsy, including α subunits, such as Nav1.1 (SCN1A), Nav1.2 (SCN2A), Nav1.3 (SCN3A), Nav1.6 (SCN8A), and Nav1.7 (SCN9A), and the β subunit (SCN1B) (7). The gene discussed is SCN8A; the disease is epilepsy.