The main diagnosis of children with SCN1A variants was Dravet syndrome (DS) (72.7%), whereas patients with SCN2A and SCN8A variants were mainly diagnosed with various types of epileptic encephalopathy, accounting for 85.7% (12 of 14) and 88.9% (8 of 9) respectively. The gene discussed is SCN2A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.