With regard to epilepsy diagnosis, SCN1A variant patients were chiefly diagnosed with DS (72.7%, 40 of 55), and the remaining patients were diagnosed with unclassified epileptic encephalopathy (EE), GEFS+, complex febrile seizure (CFS), FS+, and West syndrome. The gene discussed is SCN1A; the disease is Epileptic encephalopathy.