The ubiquitination of caveolin 1 (CAV1) mediated by zinc and ring finger 1 (ZNRF1) is blocked by circFARP1, thus leading to the release of leukemia inhibitory factor (LIF1) in cancer-associated fibroblasts (CAFs) and eventually promoting GEM resistance (Hu et al., 2022). The gene discussed is ZNRF1; the disease is cancer.