USP10 decreases ubiquitin-mediated degradation of YAP1 and further elevates cysteine-rich 61 (Cyr61), which then restores programmed cell death 1 ligand 1 (PD-L1) and galectin-9 expression and stimulates M2 polarization, thereby helping tumor cells evade from immune surveillance (Liu et al., 2022). The gene discussed is USP10; the disease is neoplasm.