Ring finger protein 43 (RNF43), as a crucial tumor suppressor, inhibits KrasG12D-dependent tumorigenesis in PDAC cells through single-cell sequencing analysis of KPC (LSL-Kras(+/G12D); LSL-Trp53(+/R172H); Pdx1-Cre) mice (Mishra et al., 2020; Hosein et al., 2022). The gene discussed is RNF43; the disease is neoplasm.