INS and obesity due to melanocortin 4 receptor deficiency: This is consistent with the lower insulin sensitivity and higher triglyceride levels reported in Hispanic children with obesity compared to Caucasians (Martos-Moreno et al., 2020), thus suggesting an eventual ethnic driven influence in obesity associated metabolomic profiles (Butte et al., 2015), although this does not extend to all difference observed (i.e., higher cholesterol ester levels in metabotype 3, not endorsed in inter-ethnic comparisons) (Martos-Moreno et al., 2019; Martos-Moreno et al., 2020).