In addition, we also observed that the downregulated miRNAs in EAF, including miR-122-5p, miR-34c-5p and ssc-miR-320a-3p, were predicted to target RAD1, RAD9B and E2F1 respectively, which were essential for DNA damage repair (Sarangi et al., 2014; Seol et al., 2018; Bigot et al., 2019; Manickavinayaham et al., 2019). Here, E2F1 is linked to epilepsy with auditory features.