In addition, the ssc-miR-34c-5p and ssc-miR-320-3p downregulated in EAF were predicted to target the MAP2K1 and MAPK1 from the p38/MAPK signaling, which was activated by estrogen receptor a or ß (Klinge et al., 2005; Li et al., 2016; Liu et al., 2019b). The gene discussed is MAP2K1; the disease is epilepsy with auditory features.