Gene expression analyses have shown differential expression of the Crp3 paralogs Crp1 and Crp2 in aneurysmal disease (Hinterseher et al., 2012; Matsumoto et al., 2014) and the absence of Crp2 was recently found to prevent angiotensin II-induced AAA in mice (Chen et al., 2022). Here, CSRP3 is linked to triple-A syndrome.