In the univariable analysis, treatment allocation with RT-TACE-LEN was a significantly favorable factor for both PFS and OS, while older age, gender of male, lager tumor size, tumor number of more than 1, higher grade of PVTT, Child-Pugh class A, higher AFP level, Hepatitis B virus infection and Hepatitis C virus infection showed no statistical difference (Table 3). The gene discussed is AFP; the disease is hepatitis B virus infection.