CLCN2 and epilepsy: Before the identification of CLCN2-related leucoencephalopathy and ataxia, heterozygous variants in CLCN2 were reported to be a cause of dominant idiopathic generalized epilepsy,23–28 but this finding was later refuted.29,30 Depienne et al. 1 suggested that pathogenic variants in CLCN2 were not associated with epilepsy after none of their six patients and heterozygous asymptomatic relatives had epilepsy.