Regarding the literary scenario on associations between the investigated TLR3 SNPs and infections, several studies have already linked the rs3775291 SNP with infectious diseases (Lee et al., 2013; Chen et al., 2017b; Santos et al., 2019; Posadas-Mondragón et al., 2020; Redondo et al., 2022a). This evidence concerns the gene TLR3 and infectious disease.