Osteopractic total flavone (OTF) has the effect of resisting osteoporosis, improving bone density and inducing osteogenesis of cells by increasing the activity of alkaline phosphatase, the level of osteocalcin, the expression of type I collagen, osteocalcin and osteopontin mRNA [18, 19]. The gene discussed is BGLAP; the disease is osteoporosis.