A study showed that drug-resistant tumour tissues from gastric cancer patients were enriched in CAFs, which promoted the development of chemoresistance by secreting IL-11 and activating the IL-11/IL-11 receptor/glycoprotein 130/Janus kinase/STAT3 anti-apoptotic signalling pathway in gastric cancer cells, thus targeting IL-11 to CAFs could alleviate drug resistance (61). The gene discussed is STAT3; the disease is gastric cancer.