CXCL1 and metabolic dysfunction-associated steatohepatitis: This suggests that NETs or NE are not indispensable for the onset of CXCL1-induced NASH (138).Neutrophils in patients with liver cancer exhibit elevated levels of mitochondrial ROS (mitoROS) and generate NETs that are enriched with oxidation products of mitochondrial DNA (mtDNA) in a manner dependent on mitoROS (139).