Currently, numerous studies have shown that P/V-CPI- increases the killing effect on tumor cells by promoting the production of double-stranded RNA, activating caspase-dependent death pathways, interfering with the DNA damage repair response in tumor cells, abrogating PKR-mediated protein synthesis, and forming extensive syncytia, etc., (Wansley et al., 2003, 2005; Dillon et al., 2006; Gainey et al., 2008a; Kedarinath and Parks, 2022). The gene discussed is EIF2AK2; the disease is neoplasm.