The latter carried a homozygous pathogenic PINK1 variant (p.L369P) and had an AAO of 32 years (Arena and Valente, 2017) reported a similar finding, where homozygous variants in PINK1 associated with early-onset PD (EOPD) were present in the patient before the age of 45 years. The gene discussed is PINK1; the disease is Parkinson disease.