Previous studies reported that carriers of digenic variants in PRKN and PINK1 develop the disease at a younger age and exhibit distinctive symptoms such as schizophrenia, facial dyskinesia, grimacing and severe dysarthria (Funayama et al., 2008) and also epilepsy and essential tremor (Hayashida et al., 2021). The gene discussed is PRKN; the disease is essential tremor.