Homozygous or compound heterozygous variants in this gene were the most common cause of EOPD (Kilarski et al., 2012), while heterozygous loss of PRKN function may be a potential risk factor for developing PD (Klein et al., 2007; Huttenlocher et al., 2015; Castelo Rueda et al., 2021; Lubbe et al., 2021) and therefore identifying individuals at increased risk might be useful in the prodromal phase. Here, PRKN is linked to Parkinson disease.