Several studies have also reported the role of the transcription factor AP1 (activator protein 1), NFkB (nuclear factor k beta), SP 1, NRF2 (nuclear factor-erythroid factor 2), and TFEB (transcription factor EB) in initiating the process of neuro degeneration that might lead to the development of AD (Rai et al., 2021b). This evidence concerns the gene NFE2 and Alzheimer disease.