MAPK8 and early-onset autosomal dominant Alzheimer disease: Dysregulation of Wnt signaling (wingless/integrated), the AKT pathway, MAPK/ERK pathway, JNK pathway (Jun N-terminal kinase), RAGE (receptor for advanced glycation end products) pathway, and AMPK (AMP-activated protein kinase) pathway have also been reported in previous studies and have been linked to the pathogenesis of Alzheimer’s disease (Atzori et al., 2001; Greco et al., 2009; Exil et al., 2014; Loera-Valencia et al., 2021; Ramakrishna et al., 2023).