The RFS graphs depicted that augmented levels of ADH4 and FBP1 show higher RFS compared to ALDOC and PFKFB3 which show higher RFS at their low levels of mRNA expression (P < 0.05) (Fig. 5B). Additionally, these deregulated genes show correlation with clinical physiological features in breast cancer individuals. This evidence concerns the gene PFKFB3 and breast carcinoma.