PFKFB3 and breast cancer: The heat map showed that all the 8-dysregulated glucose related genes are highly downregulated in BC as compared to their normal tissues (Fig. 1). The expression pattern of extremely deregulated glucose related genes across several BC subclasses using UALCAN database showed that very low expression of ADH1C, ADH4, ALDH1A3, ALDOC, PCK1, PFKFB1, and PFKFB3 in all BC subtypes including Luminal when compared to the normal patients (Fig. 2).