Whereas, very low expression of ADH1C, ADH4, ALDH1A3, ALDOC, PCK1, PFKFB1, and PFKFB3 was seen in all BC subtypes including Luminal when compared to the normal patients (Fig. 2). Furthermore, the expression of highly deregulated genes in different malignancies examined through Timer database also reflected that these genes are downregulated in tumor individuals in contrast to normal ones (Fig. 3). This evidence concerns the gene PFKFB3 and breast cancer.