Moreover, PLA2s have previously been linked with atopic disorders.99–105 Exposure to HDM stimulated the cutaneous recruitment of CD1a-responsive T cells and production of various cytokines: IL-4, IL-5, IL-13 and GM-CSF.41 Additionally, skin HDM-specific CD1a-reactive T cells responded to bee venom PLA2 indicating the presence of multi-PLA2-responsive CD1a-reactive T cells in AD. The gene discussed is CSF2; the disease is Alzheimer disease.