The findings of our study demonstrate a clear association between the expression of PTPN3 and immune-inhibitor genes, such as PVRL2 and TGFB1, as well as multiple immuno-stimulator genes, such as IL6R, NT5E, RAET1E, TMIGD2, and chemokines including CCL18, CX3CL1, CXCL3, CXCL5, CXCL14, and CXCL16 in various types of cancer. This evidence concerns the gene NECTIN2 and cancer.