The findings of our study demonstrate a clear association between the expression of PTPN3 and immune-inhibitor genes, such as PVRL2 and TGFB1, as well as multiple immuno-stimulator genes, such as IL6R, NT5E, RAET1E, TMIGD2, and chemokines including CCL18, CX3CL1, CXCL3, CXCL5, CXCL14, and CXCL16 in various types of cancer. Here, TMIGD2 is linked to cancer.