Peng et al. also found that PTPN3 was downregulated in KIRC, and restoration of PTPN3 could inhibit tumor cell motility by suppressing the phosphorylation of AKT, subsequently inactivating the PI3K/AKT signaling pathway of renal cell carcinoma cells [24]. The gene discussed is PTPN3; the disease is hereditary clear cell renal cell carcinoma.