We found an association between PTPN3 expression and TMB in 8 cancers, suggesting that the overexpression of PTPN3 was positively connected with TMB in ACC, UCEC, THYM, STAD, and PAAD while negatively correlated with TMB in COAD, CESC, and SKCM (Fig. 10A). The gene discussed is PTPN3; the disease is cancer.