The top five most significant hypomethylated DMCs mapped to GOLGA3, COL5A1, and COQ7. Of the hypomethylated genes, GOLPH3 promotes cell proliferation by enhancing the activity of AKT-mTOR signaling and plays a key role in tumor proliferation and cell cycle regulation of prostate cancer [22]. This evidence concerns the gene COL5A1 and neoplasm.