SP1 and Familial prostate cancer: 546 hypermethylated promoter motifs were significantly associated with prostate cancer (Additional file 9: Table S8) and the top three were SP2 (OR = 5.52, FDR Q-value = 6.3 × 10–98), SP1 (OR = 4.84, FDR Q-value = 8.6 × 10–103), and SP3 (OR = 4.44, FDR Q-value = 1.8 × 10–102) (Fig. 7B).