The second layer returns tumor, immune (naïve B, memory B, CD4 naïve T, CD4 memory T, regulatory T, CD8 naïve T, CD8 memory T, monocyte, dendritic cell, natural killer, basophil, eosinophil, and neutrophil cells), and angiogenic (endothelial, epithelial, and stromal cells) cell-type proportions. Here, CD8A is linked to neoplasm.