193 hypomethylated promoter motifs were significantly associated with prostate cancer (Additional file 8: Table S7) and the top three were FOXA2 (OR = 3.15, FDR Q-value = 6.6 × 10–10), FOXA1 (OR = 2.89, FDR Q-value = 9.1 × 10–9), and FOXA3(OR = 2.89, FDR Q-value = 1.2 × 10–7) (Fig. 7A). This evidence concerns the gene FOXA2 and Familial prostate cancer.