Regionally (Fig. 4A), synaptophysin density showed a strong negative correlation with NfL immunoreactivity specifically in the regions affected at Braak 6 in DLB cases (r = -0.68, R2 = 46%, p = 0.048), and not in any region of any other groups (p > 0.05). This evidence concerns the gene NEFL and Lewy body dementia.