Regionally (Fig. 5A), synaptophysin density negatively correlated with LB density in regions affected at Braak 4 in PD (r = -0.46, R2 = 21%, p = 0.011) and DLB groups (r = -0.48, R2 = 23%, p = 0.005), and in regions affected at Braak 6 in PDD (r = -0.55, R2 = 30%, p = 0.039). The gene discussed is SYP; the disease is Lewy body dementia.