As such, the aim of this study was to map and quantify synaptic loss with the pre-synaptic markers synaptophysin and SV2A in eight cortical brain regions commonly affected in PD(D) and DLB, and to assess whether regional differences in the pattern of synaptic loss are linked to axonal degeneration and neuropathological burden. Here, SV2A is linked to Lewy body dementia.