Furthermore, we found that the pattern of synaptic degeneration differed between PD and PDD/DLB cases: in PD temporal, cingulate and insular cortices affected at Braak α-synuclein stage 5 showed more pronounced synaptic degeneration compared to controls, while PDD and DLB cases additionally showed synaptic degeneration in parahippocampal regions affected at Braak α-synuclein stage 4. This evidence concerns the gene SNCA and Parkinson disease.