A significant difference was found in Ab42/T-Tau ratio comparing 12 CBS and 21 PSP patients (0.86, 95% CI 0.74–0.98) [15] In addition, Lysosomal network proteins LC3, EEA1 and lysozyme levels resulted higher in 10 CBS patients compared to healthy controls [22]; however, the difference resulted statistically significant only for LC3 (92% higher in CBS than controls; p < 0.001). The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.