In a mixed cohort of 11 CBS and PSP patients, T-Tau levels showed a correlation with progranulin (r = 0.192, p = 0.001) [21]; furthermore, in a cohort of 11 CBS patients, T-Tau levels correlated with 24- S-Hydroxycholesterol, 24- OHC (r = 0.98, p < 0.001), whilst no significant association was found with 27- S-Hydroxycholesterol (27-OHC) levels, suggesting a direct interaction between the neuronal production of 24-OHC and T-Tau [32]. The gene discussed is GRN; the disease is supranuclear palsy, progressive, 1.