TARDBP and frontotemporal dementia: GRN frontotemporal dementia (GRN-FTD) generally affects the frontal and temporal cortex leading to behavioural changes, executive disfunction, and language disturbances; however, in some cases the parietal cortex and basal ganglia may be affected as well, resulting in parkinsonism and corticobasal syndrome [4], as such, GRN mutation might represent a possible underinvestigated cause of CBS associated with TDP-43 neuropathology.