PSEN1 and Alzheimer disease: As VEGFR1 and VEGFR2 are the main receptors that mediate VEGF function, increased cortical levels of VEGFR2 at 10–12 months of age in APP/PS1 and 5×FAD mice and decreased levels of VEGFR1 in the parietal cortex of AD patients and in the brains of 10- to 11-month-old male APP/PS1 mice have been reported previously [11, 23, 79].