INS and Hypoglycemia: The once-weekly insulin icodec was associated with a lower incidence of severe hypoglycemia compared to the once-daily deglude (RR 0.00016 [95% CI 0 to 0.41], Fig. 3) and no significant difference was observed between once-weekly insulin icodec and once-daily glargine (RR 0.39 [95% CI 0.03 to 4.83]).There were no significant differences between once-weekly insulin icodec and once-weekly insulin Fc (RR 0.94 [95% CI 0.54 to 1.67]), once-daily glargine (RR 1.20 [95% CI 0.92 to 1.49) and once-daily deglude (RR 1.30 [95% CI 0.98 to 1.70]) in terms of hypoglycemia alerts episodes (Fig. 4).