In human subjects, SELENOS expression level in subcutaneous and omental adipose tissue were elevated in the obese subjects and in T2DM patients, and levels of SELENOS were correlated positively with body mass index (BMI), serum levels of high density lipoprotein cholesterol (HDL-C), TG, and insulin resistance assessed by the homeostasis model assessment (HOMA-IR) [7–9]. Here, SELENOS is linked to type 2 diabetes mellitus.