Furthermore, the silencing of SELENOS via small interference RNA (siRNA) was found to significantly exacerbate the inflammatory response, apoptosis, and oxidative stress in hepatoma HepG2 and Hepa1-6 cells induced by β-mercaptoethanol (an ER stress agent) and lipopolysaccharide (LPS) [68–70]. The gene discussed is SELENOS; the disease is hepatocellular carcinoma.