The endoplasmic reticulum (ER) stress, linked with vascular ED, includes the activation of the inositol requiring enzyme 1 (IRE1) and activating transcription factor 6 (ATF6) pathways, and the induction of activating transcription factor 4 (ATF4) [24–26]. The gene discussed is ERN1; the disease is Ehlers-Danlos syndrome, vascular type.