For example, the substantially increased number of T2D cases and controls that were meta-analysed for TCF7L2 led to correspondingly low P-values but with ORs still close to 1.0 (Table 3), while our OR estimates for the same TCF7L2 SNPs ranged from 1.73 to 2.04. Here, TCF7L2 is linked to type 2 diabetes mellitus.