Given parkin's role as an SCF-like ubiquitin ligase complex component, potential substrates degraded by parkin, such as aminoacyl-tRNA synthetase interacting multifunctional protein 2 (AIMP2, also known as p38 or JTV-1) [15, 52], have emerged as promising therapeutic targets for PD. The gene discussed is AIMP2; the disease is Parkinson disease.