In particular, Rho-Associated Protein Kinase 1 (ROCK1) and Apoptosis Signal–Regulating Kinase 1 (ASK1) (MAP3K5) are found to play an important role in the progression of NAFLD to NASH through mediating lipotoxic effects [15]. The gene discussed is MAP3K5; the disease is metabolic dysfunction-associated steatotic liver disease.