STAT3 and cancer: Janus kinase2/signal transducer and activator of the transcription3 (JAK2/STAT3) signaling pathway plays an important role in the growth, migration and transformation of cancer cells, and studies have shown that LNT can inhibit JAK2/STAT3 signaling pathway by regulating miR-216a-5p, thereby promoting apoptosis in lung cancer [51].