Zhu et al. randomized controlled studies found that LNT combined with GP (guitar cesibin combined with cisplatin) chemotherapy improved the effective CD4/CD8 ratio and better quality of life in patients with advanced lung cancer compared with GP chemotherapy alone, and had fewer adverse reactions such as gastrointestinal reactions [54] Moreover, another study also found that LNT combined with GP enhanced the immune function of CD4 and NK cells in patients with advanced non-small cell lung cancer [55]. Here, CD4 is linked to lung cancer.