When the genes were plotted in a KEGG graph-network a number of the genes in the signature (JAG1, HEY1, HEY2 and HEYL) linked to the term “breast cancer”, while the same four genes plus PDGFRB and KIT linked to the term “pathways in cancer” (Fig. 3C; for full list of enriched pathways, GO terms and detailed CSL binding site information, see Additional file 7: Table S5). This evidence concerns the gene RBPJ and breast cancer.