Recently, NECTIN2 variants were shown to be associated with AD risk as well as with altered lipid metabolism and conferring cardiovascular risk in people with type 2 diabetes mellitus [56] Furthermore, one of the SNPs in the human NECTIN2 gene, is significantly associated with AD in African Americans, even after adjusting for the effects of APOE genotype [57]. This evidence concerns the gene APOE and type 2 diabetes mellitus.