Finally, the A allele of rs11666329, an intronic NECTIN2 variant, was associated with lower sTREM2 levels (β=-0.13, P=2.5×10-8) and higher AD risk (β=0.21, P= 1.27×10-41, Kunkle et al 2019 [7]; β=0.17, P= 1.52×10-66, Schwartzentruber et al 2021 [30]). This evidence concerns the gene NECTIN2 and Alzheimer disease.