TREM2 and Alzheimer disease: Individuals carrying the minor allele of any of the three TREM2 missense variants known to be associated with AD risk [2, 3] exhibited lower CSF sTREM2 levels (rs142232675, p.D87N, β =-1.843, P=2.71×10-10; rs143332484, p.R62H, β =-0.551, P=6.02×10-7; rs75932628, p.R47H, β =-1.349, P=7.16×10-19).