Notably, our two new signals, chromosome 3 (TGFBR2/RBMS3) and chromosome 19 (NECTIN2/APOE), did not showed any association with plasma sTREM2 (P>0.17), suggesting these are CSF specific signals and reinforming the notion that it is important to study relevant tissues other than plasma for AD. The gene discussed is APOE; the disease is Alzheimer disease.