Apart from the glycemic status, Karamali et al. proved the ameliorating effect of probiotics on total testosterone, sex hormone-binding globulin (SHBG), modified Ferriman Gallwey (hirsutism indicator tool), high-sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC) and malondialdehyde (MDA) levels in women with PCOS [47]. This evidence concerns the gene SHBG and Hirsutism.