For example, a 40-year-old unmarried BCLM patient was diagnosed with invasive lobular carcinoma (ILC), grade III, HER2 (-), ER ( +), PR ( +), with liver metastases, without bone or brain metastases, who underwent surgery and chemotherapy but did not receive neoadjuvant therapy, has a quantified score of 280 by the nomogram, and the predictive OS at 1-, 2-, and 3-year were 73%, 55%, and 44%, respectively. This evidence concerns the gene ESR1 and invasive lobular breast carcinoma.