BRCA1 and breast carcinoma: Interestingly, reports addressing the effects of parent-of-origin on disease development reported that paternal inheritance of BRCA resulted in an earlier age of diagnosis of breast and ovarian cancer [7] and that the risk of developing breast cancer was modestly higher in women with a paternally-inherited BRCA1 mutation compared to maternally-inherited BRCA1 mutation, but not for women with a BRCA2 mutation [18].