Through the univariate Cox analysis, we identified 14 significant FRGs (SPRR2E, MYBPH, SOST, CYP4F8, HMGCS2, PDZD3, SPRR2A, BHMT, CRNN, LCE3D, CRTAC1, LRTM1, DSG3, KRT6B) as independent prognostic indicators for BLCA (Fig. 7a). This evidence concerns the gene LCE3D and bladder transitional cell carcinoma.