SPRR2E and bladder transitional cell carcinoma: Through the univariate Cox analysis, we identified 14 significant FRGs (SPRR2E, MYBPH, SOST, CYP4F8, HMGCS2, PDZD3, SPRR2A, BHMT, CRNN, LCE3D, CRTAC1, LRTM1, DSG3, KRT6B) as independent prognostic indicators for BLCA (Fig. 7a).