Through the univariate Cox analysis, we identified 14 significant FRGs (SPRR2E, MYBPH, SOST, CYP4F8, HMGCS2, PDZD3, SPRR2A, BHMT, CRNN, LCE3D, CRTAC1, LRTM1, DSG3, KRT6B) as independent prognostic indicators for BLCA (Fig. 7a). This evidence concerns the gene CRTAC1 and bladder transitional cell carcinoma.