CD8A and neoplasm: As the key cytotoxic cells of TME, high infiltration groups of CD8 + T cells estimated by immunohistochemistry in different regions, or by CIBERSORT deconvolution according to RNA-sequencing data, were related with better survival under IO/TKI, (high CD8 + T cells in tumor center, HR = 0.53, P < 0.001; high CD8 + T cells in invasive margin, HR = 0.55, P = 0.010; high CD8 + T cells in total area, HR = 0.54, P < 0.001; high CD8 + T cells by CIBERSORT, HR = 0.59, P = 0.001; Fig. 2A).