Sixty-seven samples were analyzed for IDH1 p.R132H mutation in cfDNA and tissue; in particular, 10 samples (15%) were positive both in tissue and in cfDNA (T+/P+), while five patients (7.3%) were IDH1 wild type in tumor tissue but positive in cfDNA (T−/P+). Finally, 11 patients were found to have IDH1 mutated tumor tissue and no IDH1 mutation in plasma (16.4%) (Fig. 1a). This evidence concerns the gene IDH1 and neoplasm.