In the previous study of our research group [15], we found that knocking down miR-26a-5p can improve pathological cardiac hypertrophy by regulating autophagy, but whether miR-26a-5p regulates autophagy is associated with NLRP3 inflammasome, which leads to the aggravation of pathological cardiac hypertrophy, and the regulatory mechanism between them need further study. This evidence concerns the gene NLRP3 and cardiac hypertrophy.