Our research results have enhanced the understanding of the NLRP3 inflammasome signalling pathway on the pathological mechanism of cardiac hypertrophy; In addition, miR-26a-5p regulates autophagy and activates the NLRP3 inflammasome, thus mediating cardiomyocyte hypertrophy, These findings introduce novel insights for early diagnosis and drug development in the treatment of cardiac hypertrophy. This evidence concerns the gene NLRP3 and cardiac hypertrophy.